Araştırma Makalesi
Myrtus communis L. (Mersin) Yaprak Ekstraktının Genoprotektif Etkisinin Somatik Mutasyon ve Rekombinasyon Testi ile Değerlendirilmesi
Öz
Bu çalışmada Myrtus communisL. (mersin) yaprak ekstraktının genoprotektif etkisi somatik mutasyon ve rekombinasyon testi (SMART) ile incelendi. Yüksek genotoksik etkiye sahip kemoterapötik bir ajan olan doksorubisin (DXR) pozitif kontrol olarak kullanıldı. Test maddeleri flare (flr3) ve çoklu kanat kılı (mwh) mutant işaret genlerini taşıyan üç günlük (72 ± 4 saat) transheterozigot Drosophila melanogaster larvalarına uygulandı. Mersin yaprak ekstraktı, genotoksik etkisini değerlendirmek için tek başına (1,5 ve 10 mg/mL) ve antigenotoksik etkisini değerlendirmek için doksorubisin (0,125 mg/ml) ile birlikte uygulandı. İnhibisyon yüzdeleri 1, 5 ve 10 mg/mL dozlarında sırasıyla %91.70, % 97.51 ve % 98.34 olarak hesaplandı. Bu çalışmadan elde edilen sonuçlar mersin yaprak ekstraktının test edilen tüm dozlarda doksorubisin kaynaklı mutant klon oluşumunu inhibe ederek antigenotoksik etki gösterdiğini ortaya koymuştur.
Anahtar Kelimeler
Myrtus communis L. antigenotoksisite doksorubisin Drosophila melanogaster
Destekleyen Kurum
Kırıkkale Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi
Proje Numarası
2012/010
Teşekkür
Bu çalışma Kırıkkale Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi tarafından desteklenmiştir (Proje No: 2012/010).
Kaynakça
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Toplam 39 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Proje Numarası | 2012/010 |
| Yayımlanma Tarihi | 30 Eylül 2019 |
| Gönderilme Tarihi | 13 Haziran 2019 |
| Kabul Tarihi | 20 Ağustos 2019 |
| Yayımlandığı Sayı | Yıl 2019 Cilt: 8 Sayı: 3 |
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